Pediatric anesthesia & critical care
Cognition and Anesthesia Exposure in Adolescent and Young Adult Retinoblastoma Survivors
Authors' conclusion
Despite any effects of repeated anesthesia exposure in early childhood on cognition, MoCA scores for RB survivors were in the normal range.
Study context
- Population
- 14- to 26-year-old retinoblastoma (RB) survivors and healthy controls
- Participants
- 98 vs 97
- Exposure
- RB survivors vs healthy controls; anesthesia exposure and cognition
- RBn = 98
- Controlsn = 97reference
- Outcome
- Cognitive function (Montreal Cognitive Assessment, MoCA)
Main finding
As reported in the abstract
RB patients scored significantly lower than controls on the Montreal Cognitive Assessment (MoCA) and several subscales (Naming, Attention, Language, Abstraction)
adjusted ps < 0.05
Total childhood anesthesia exposure negatively associated with MoCA total scores (ρ)
−0.19
p = 0.009
Each anesthetic before age 3 associated with decrease in cognition (adjusted β)
−0.06
p = 0.02
Each anesthetic throughout childhood associated with decrease in cognition (adjusted β)
−0.04
p = 0.005
Observational data: associations, not effects.
Further findings
Other predictors of MoCA total scores
- Hollingshead socioeconomic status (β)
- 0.04, p = 0.001
- Public insurance (β)
- −1.75, p < 0.0001
- Stronger predictors than anesthesia exposure
Original publication
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