Combined Dexamethasone and Dexmedetomidine as Adjuncts to Popliteal and Saphenous Nerve Blocks in Patients Undergoing Surgery of the Foot or Ankle: A Randomized, Blinded, Placebo-controlled Clinical Trial
Authors' conclusion
Dexamethasone with or without dexmedetomidine increased the duration of analgesia in patients undergoing surgery of the foot or ankle with a popliteal (sciatic) and saphenous nerve block. Combined dexamethasone and dexmedetomidine did not increase the duration of analgesia when compared with dexamethasone.
Study context
- Population
- Patients undergoing foot or ankle surgery under GA with combined popliteal (sciatic) and saphenous nerve block119 analysed
- Participants
- 120 patients
- Comparison
- Dexamethasone and dexmedetomidine vs Dexamethasone vs Placebo
- Primary endpoint
- Duration of analgesia (time from block performance to first sensation of pain in surgical area, participant-reported; 33% difference predefined as clinically relevant)
Methodological detailsblinded, placebo-controlled, two centres
- Blinded
- Placebo-controlled
- Two centres
Primary result
As reported in the abstract
Duration of analgesia
Difference, min (98.33% CI)P value
Dexamethasone and dexmedetomidine vs Placebo
564(301–794)
P < 0.001Dexamethasone vs Placebo
489(265–706)
P < 0.001Dexamethasone and dexmedetomidine vs Dexamethasonesimilar duration
61(−222 to 331)
P = 0.614Original publication
Combined Dexamethasone and Dexmedetomidine as Adjuncts to Popliteal and Saphenous Nerve Blocks in Patients Undergoing Surgery of the Foot or Ankle: A Randomized, Blinded, Placebo-controlled Clinical Trial. Anesthesiology. Published 14 March 2024. doi:10.
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