Perioperative medicine & outcomes

Comfort-Focused Assessment and Patient-Reported Experience After Regional versus General Anaesthesia: Post Hoc Analysis of a Cluster-Randomised Trial

Anaesth Crit Care Pain MedPublished Post hoc subgroup analysis of the COMFORT cluster-randomised trial

Authors' conclusion

Replacing the NRS with a comfort-focused approach did not improve global patient experience after surgery.

Study context

Population
Adults undergoing elective non-cardiac surgery managed in the post-anaesthesia care unit (PACU), divided into regional anaesthesia (RA) and general anaesthesia (GA) subgroups786 with evaluable EVAN data · divided into RA 305 · GA 481
Participants
885 adults
Comparison
Comfort-focused scale vs pain NRS in the PACU, by RA vs GA subgroup
Primary endpoint
Patient-reported experience (EVAN-G/LR scales, self-completed on the ward/day-care unit)
Follow-up
≥4 h postoperatively
Methodological detailsmulticentre (29 French centres)
  • Multicentre (29 French centres)

Primary result

As reported in the abstract

EVAN Pain score, RA subgroup (n = 305)

Comfort

88

median · IQR 75–94

NRS

75

median · IQR 69–88

P = 0.034

Further findings

Nefopam use, RA subgroup

P = 0.005

Median

OutcomeComfortNRSP value
EVAN Waiting score, RA subgroup100 (IQR 75–100)— not stated in the abstractP = 0.012
EVAN Global Index, RA subgroup81 (IQR 72–91)77 (IQR 68–90)P = 0.044

— not stated in the abstract

EVAN scores, GA subgroup (n = 481)

EVAN scores similar between groups

Antiemetic use, GA subgroup

Antiemetic use lower with the comfort approach in GA

Original publication

Comfort-Focused Assessment and Patient-Reported Experience After Regional versus General Anaesthesia: Post Hoc Analysis of a Cluster-Randomised Trial. Anaesth Crit Care Pain Med. Published 31 October 2025. doi:10.1016/j.accpm.2025.101660

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