Pediatric anesthesia & critical care
Comparative Effectiveness of Analgesia for Early Pain Management After Pediatric Tonsillectomy: A Systematic Review and Network Meta-Analysis
Study context
- Population
- Children (≤18 years old) undergoing tonsillectomy with or without adenoidectomy
- Participants
- 6,110 children · 82 RCTs
- Comparison
- Analgesics for pediatric tonsillectomy
- Outcome
- Pain score and postoperative complications
Methodological detailsrandom-effects model
- Random-effects model
Pooled result
As reported in the abstract
Pain score; postoperative complications
MD (95% CI)P value
NSAIDs except ketoprofenpain score; no significant effects
−2.96(−5.59 to −0.32)
P = 0.10Bupivacaine vs placebopain score; effective
−2.76(−3.88 to −1.64)
P = 0.01Ropivacaine vs placebopain score; effective
−2.49(−4.25 to −0.73)
P = 0.02Lidocaine vs placebopain score; effective
−1.86(−3.52 to −0.2)
P = 0.02Levobupivacaine vs placebopain score; effective
−1.06(−2.00 to −0.12)
P = 0.01Morphine vs placebopain score; effective
−2.07(−3.14 to −1.00)
P = 0.02Dexamethasone vs placebopain score; effective
−0.45(−0.73 to −0.16)
P = 0.01Relative risk (95% CI)P value
Dexamethasone vs Bupivacainepostoperative complications; dexamethasone superior
0.60(0.43–0.83)
P = 0.02Further pooled results
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| Patients needing rescue analgesiaLevobupivacaine vs Lidocaine | 0.51 (0.32–0.81) | P = 0.01 | |
| Patients needing rescue analgesiaMorphine vs Lidocaine | 0.44 (0.25–0.75) | P = 0.01 | |
| Patients needing rescue analgesiaMorphine vs Ropivacaine | 0.54 (0.32–0.91) | P = 0.01 | |
| 0.20.5125Relative risk (log scale) |
| Outcome | P value |
|---|---|
| Patients needing rescue analgesiaMorphine vs Bupivacaine · not different | P = 0.10 |
| Patients needing rescue analgesiaMorphine vs Levobupivacaine · not different | P = 0.12 |
Original publication
Comparative Effectiveness of Analgesia for Early Pain Management After Pediatric Tonsillectomy: A Systematic Review and Network Meta-Analysis. Anesth Analg. Published 20 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →