ICU sedation, delirium & recovery
Comparing Bispectral Index Monitoring vs Clinical Assessment for Deep Sedation in the ICU: Effects on Delirium Reduction and Sedative Drug Doses-A Randomized Trial
Authors' conclusion
In this study, BIS-guided deep sedation did not improve DFCF days, but did reduce sedative drug use.
Study context
- Population
- ICU patients requiring deep sedation (RASS −4 or −5) for > 8 h
- Participants
- 99 patients
- Comparison
- BIS-guided deep sedation vs clinical assessment
- Primary endpoint
- Number of delirium-free and coma-free (DFCF) days
- Follow-up
- 14 days after deep sedation
Methodological detailssingle-centre, tertiary mixed ICU, masked outcome assessment
- Single-centre
- Tertiary mixed ICU
- Masked outcome assessment
Primary result
As reported in the abstract
DFCF days
- No significant difference in delirium-free and coma-free (DFCF) days between clinical assessment (CA) and BIS
- BIS vs CA: P = 0.1
Further findings
Propofol dose · during deep sedation · significantly lower in BIS
P = 0.03
| Outcome | CA | BIS | P value |
|---|---|---|---|
| Proportion of total hours with BIS values < 40 · during deep sedation | 46% (95% CI 35%–57%) | 32% (95% CI 25%–40%) | P = 0.03 |
| DFCF days (subgroup sedated > 24 h) · 14 days after deep sedationSubgroup analysis | median 1 (IQR 0-9 days) day | median 8 (IQR 0-13 days) days | P = 0.04 |
Original publication
Comparing Bispectral Index Monitoring vs Clinical Assessment for Deep Sedation in the ICU: Effects on Delirium Reduction and Sedative Drug Doses-A Randomized Trial. Chest. Published 18 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →