Neuroanesthesia & neurocritical care
Comparing General Anesthesia–Based Regimens for Endovascular Treatment of Acute Ischemic Stroke: A Systematic Review and Network Meta-Analysis
Authors' conclusion
This network meta-analysis showed that the perioperative use of either general anesthesia-based regimen, or sedation, did not significantly impact various endovascular therapy-related outcomes.
Study context
- Population
- Adults with acute ischemic stroke undergoing endovascular therapy
- Participants
- 3,015 adults · 15 studies
- Comparison
- Total intravenous anesthesia (TIVA)-based vs volatile-based GA
- TIVAn = 1,212
- Volatilen = 736reference
- Conscious sedationn = 1,067
- Outcome
- Favorable functional outcome (mRS ≤2)
- Follow-up
- 90 days
Pooled result
As reported in the abstract
90-day neurological outcome
Odds ratio (95% CI)P value
TIVA vs volatile
1.25(0.81–1.91)
P = 0.31Conscious sedation vs TIVA
1.14(0.84–1.53)
P = 0.40Conscious sedation vs volatile
1.42(0.92–2.17)
P = 0.11Further pooled results
| Outcome | Estimate | P value | |
|---|---|---|---|
| 90-day mortality · 90 daysTIVA vs Volatile | OR for death 0.72 (95% CI 0.42–1.24) | P = 0.24 | |
| 90-day mortality · 90 daysConscious sedation vs TIVA | OR for death 0.87 (95% CI 0.62–1.23) | P = 0.43 | |
| 90-day mortality · 90 daysConscious sedation vs Volatile | OR for death 0.63 (95% CI 0.36–1.12) | P = 0.11 | |
| Successful recanalizationTIVA vs Volatile | OR for successful recanalization 1.33 (95% CI 0.70–2.52) | P = 0.39 | |
| Successful recanalizationConscious sedation vs TIVA | OR for successful recanalization 0.76 (95% CI 0.52–1.10) | P = 0.15 | |
| Successful recanalizationConscious sedation vs Volatile | OR for successful recanalization 1.01 (95% CI 0.52–1.94) | P = 0.98 | |
| 0.20.5125Ratio (log scale) |
| Outcome | SMD (95% CI) | P value | |
|---|---|---|---|
| Recanalization timeTIVA vs Volatile | 0.03 (−0.35 to 0.41) | P = 0.88 | |
| Recanalization timeConscious sedation vs TIVA | −0.18 (−0.47 to 0.11) | P = 0.23 | |
| Recanalization timeConscious sedation vs Volatile | −0.15 (−0.52 to 0.23) | P = 0.44 | |
| −1−0.500.5Difference (linear scale) |
90-day favourable neurological outcome (mRS ≤2), vs conscious sedation
- No significant differences
90-day mortality
- No significant differences
Successful recanalization
- No significant differences
Recanalization time
- No significant differences
Original publication
Comparing General Anesthesia–Based Regimens for Endovascular Treatment of Acute Ischemic Stroke: A Systematic Review and Network Meta-Analysis. Anesth Analg. Published 20 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →