Comparing nasopharyngeal apnoeic oxygenation at 18 l/min to preoxygenation alone in obese patients – A randomised controlled study
Authors' conclusion
Nasopharyngeal apnoeic oxygenation at 18 l/min prolongs safe apnoea time, compared to preoxygenation alone, and reduces the risk of desaturation in morbidly obese patients.
Study context
- Population
- Adult obese (BMI ≥ 35 kg.m-2) patients for elective surgery in a resource constrained hospital
- Participants
- 30 participants
- Comparison
- Nasopharyngeal apnoeic oxygenation at 18 l.min-1 vs preoxygenation only
- Primary endpoint
- Safe apnoea time (time to desaturate to SpO2 92%; observation up to 600 s)
Methodological detailsblock randomisation, 1:2 allocation
- Block randomisation
- 1:2 allocation
Primary result
As reported in the abstract
Safe apnoea time
P < 0.001
Secondary outcomes
| Outcome | HR (95% CI) | P value |
|---|---|---|
| Risk of desaturationLog-Rank test | 0,072 (0,019–0,283) | P < 0.001 |
| Rate of CO2 accumulationT-test; significantly slower in the intervention group | P = 0.003 |
Risk factors for desaturation
- No statistically significant risk factors associated with increased risk of desaturation found
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Comparing nasopharyngeal apnoeic oxygenation at 18 l/min to preoxygenation alone in obese patients – A randomised controlled study. J Clin Anesth. Published 9 May 2023. doi:10.
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