Perioperative medicine & outcomes
Comparing the post-operative complications following surgery for hip fracture of patients who were on warfarin versus patients who were on novel oral anticoagulants: a meta-analysis
Authors' conclusion
The post-operative complications following surgery for hip fracture of patients who were on warfarin versus patients who were on NOACs were similar. However, those patients who were on warfarin had a significantly longer length of hospital stay.
Study context
- Population
- Patients undergoing surgery for hip fracture while on anticoagulants
- Participants
- 15,019 patients
- Comparison
- Warfarin vs novel oral anticoagulants (NOACs) before surgery for hip fracture
- Warfarinn = 11,215
- NOACsn = 3,804reference
- Outcome
- Post-operative complications
Pooled result
As reported in the abstract
Warfarin vs NOACsRelative risk (95% CI)P value
Post-operative mortality
1.03(0.92–1.16)
P = 0.57DVT
1.10(0.41–2.98)
P = 0.84PE
1.17(0.44–3.10)
P = 0.75Stroke
1.25(0.23–6.71)
P = 0.80MI
0.42(0.03–6.98)
P = 0.55- Infection risk similar between groups
- 0.90 (RR, 0.90; 95% CI, 0.28-2.93; P = 0.87)
- Blood transfusion risk similar between groups
- 1.08 (RR, 1.08; 95% CI, 0.80-1.45; P = 0.62)
Further pooled results
| Outcome | WMD (95% CI) | P value |
|---|---|---|
| Length of hospital staySignificantly less with NOACs | - 0.93 (- 1.83 to 0.03) | P = 0.04 |
Original publication
Comparing the post-operative complications following surgery for hip fracture of patients who were on warfarin versus patients who were on novel oral anticoagulants: a meta-analysis. Perioper Med (Lond). Published 17 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →