Perioperative medicine & outcomes
Impact of direct oral anticoagulant treatment on management and outcomes of patients with hip fractures by monitoring assays. A population-based study of a cohort from the Geriatric Perioperative Unit
Authors' conclusion
DOACs were associated with higher mortality. A level of up to < 80 ng.mL-1 does not appear to make any difference to transfusion compared with no DOAC.
Study context
- Population
- Patients aged >65 yrs admitted for hip fracture to a geriatric perioperative unit, managed with early surgeryJanuary 2022 to September 2023
- Participants
- 117 vs 468
- Exposure
- DOACs vs No-DOACs
- DOACsn = 117
- No-DOACsn = 468reference
- Outcome
- Mortality
- Follow-up
- Up to Day 30
Methodological detailspopulation-based, monocenter, Registered retrospectively
- Population-based
- Monocenter
- Registered retrospectively
Main finding
As reported in the abstract
Mortality up to Day 30
- Lower 30-day mortality in the No-DOACs group
- P < 0.01
Observational data: associations, not effects.
Further findings
Transfusion rates · similar
P = 0.55
| Outcome | Median hazard-risk (CI) |
|---|---|
| Mortality up to Day 180 | 0.34 (0.19–0.59) |
Surgery with one-day delay
- DOACs patients most often operated on with a one-day delay
- P < 0.05
Transfusion and mortality by DOAC concentration subgroup (subgroup)
- Subgroups (<30, 30-50, 50-80 ng.mL-1) presented similar outcomes (transfusion, mortality)
Original publication
Impact of direct oral anticoagulant treatment on management and outcomes of patients with hip fractures by monitoring assays. A population-based study of a cohort from the Geriatric Perioperative Unit. Anaesth Crit Care Pain Med. Published 4 October 2025. doi:10.
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