Pediatric anesthesia & critical care
Comparison Between Histidine-Tryptophan-Ketoglutarate Cardioplegia and Cold Blood Cardioplegia for Myocardial Protection in Tetralogy of Fallot Patients Undergoing Surgical Repair: A Randomized Clinical Trial
Authors' conclusion
HTK cardioplegia may offer better cardiac protection to pediatric patients undergoing tetralogy of Fallot repair than our institutional standard CBC with better recovery for the hypertrophic RV.
Study context
- Population
- Children (1 to 5 years old) scheduled for tetralogy of Fallot repair
- Participants
- 100 children
- Comparison
- Histidine-tryptophan-ketoglutarate (HTK) cardioplegia vs cold blood cardioplegia
Methodological detailsdouble-blinded, parallel-group, single-centre, Ain Shams University Hospitals
- Double-blinded
- Parallel-group
- Single-centre
- Ain Shams University Hospitals
Primary result
As reported in the abstract
Vasoactive inotropic score · on PICU admission
HTK
13.0
± 4.1
CBC
15.5
± 5.4
p value of 0.011
Further findings
Lactate level · first 24 hours
P < 0.0001
| Outcome | HTK | CBC | P value |
|---|---|---|---|
| Serial troponin · first 72 hours postoperatively | 1.49 ± 0.45 | 1.69 ± 0.18 | P = 0.005 |
| Postoperative RV function (echocardiographic TAPSE and myocardial performance index)Better in HTK | P < 0.05 |
Vasoactive-inotropic score · after 24 hours
- Comparable between groups
Original publication
Comparison Between Histidine-Tryptophan-Ketoglutarate Cardioplegia and Cold Blood Cardioplegia for Myocardial Protection in Tetralogy of Fallot Patients Undergoing Surgical Repair: A Randomized Clinical Trial. J Cardiothorac Vasc Anesth. Published 23 July 2024. doi:10.
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