Pediatric anesthesia & critical care
Effectiveness of Dexmedetomidine as Myocardial Protector in Children With Classic Tetralogy of Fallot Having Corrective Surgery: A Randomized Controlled Trial
Authors' conclusion
Dexmedetomidine during CPB is an effective cardioprotective agent in TOF children having surgery.
Study context
- Population
- Indonesian children with classic tetralogy of Fallot undergoing corrective surgery with cardiopulmonary bypass (CPB)none excluded
- Participants
- 66 children
- Comparison
- Dexmedetomidine during CPB vs placebo
Methodological detailsprospective, parallel, block randomization, double-blinded preparation of treatment agents, Single centre: National Cardiovascular Center Harapan Kita, Indonesia
- Prospective
- Parallel
- Block randomization
- Double-blinded preparation of treatment agents
- Single centre: National Cardiovascular Center Harapan Kita, Indonesia
Primary result
As reported in the abstract
Troponin I · 6 and 24 hours after CPB
| Group | Value | 24 hours |
|---|---|---|
| Dexmedetomidine (DEX) | 30.48 ± 19.33 | 8.89 ± 5.42 |
| Placebo | 42.73 ± 27.16 | 14.04 ± 11.17 |
Value
Dexmedetomidine (DEX)30.48 ± 19.33
Placebo42.73 ± 27.16
24 hours
Dexmedetomidine (DEX)8.89 ± 5.42
Placebo14.04 ± 11.17
- DEX vs Placebo: P = 0.039 — 6 hours
- DEX vs Placebo: P = 0.02 — 24 hours
Further findings
| Outcome | P value |
|---|---|
| Interleukin-6 · 6 and 24 hours after CPBDEX vs Placebo · 6 hours | P = 0.03 |
| Interleukin-6 · 6 and 24 hours after CPBDEX vs Placebo · 24 hours | P = 0.035 |
| Lactate · 1, 6 and 24 hours after CPBDEX vs Placebo · 1 hour | P < 0.01 |
| Lactate · 1, 6 and 24 hours after CPBDEX vs Placebo · 6 hours | P = 0.048 |
| Lactate · 1, 6 and 24 hours after CPBDEX vs Placebo · 24 hours | P = 0.035 |
| Vasoactive inotropic score during ICU monitoring | P = 0.049 |
| Length of ventilation, ICU stayDEX vs Placebo · ventilation | P = 0.313 |
| Length of ventilation, ICU stayDEX vs Placebo · ICU stay | P = 0.087 |
| Mortality · up to 30 days | P > 0.99 |
Interleukin-6 · 6 and 24 hours after CPB
- Lower with DEX
Lactate · 1, 6 and 24 hours after CPB
- Lower with DEX
Haemodynamics · from 6 hours after bypass
- DEX increased cardiac output and index and decreased systemic vascular resistance
Vasoactive inotropic score during ICU monitoring
- Reduced with DEX
Length of ventilation, ICU stay
- Not significantly affected by DEX
Mortality · up to 30 days
- Comparable across groups
Original publication
Effectiveness of Dexmedetomidine as Myocardial Protector in Children With Classic Tetralogy of Fallot Having Corrective Surgery: A Randomized Controlled Trial. J Cardiothorac Vasc Anesth. Published 9 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →