Pediatric anesthesia & critical care
Effect of Dexmedetomidine on Cerebrovascular Carbon Dioxide Reactivity During Pediatric Cardiac Surgery With Cardiopulmonary Bypass
Authors' conclusion
A low loading dose of DEX did not compromise CVR-CO2 in children with CHD undergoing cardiac surgery with cardiopulmonary bypass.
Study context
- Population
- Children aged 0 to 6 years with congenital heart disease undergoing cardiac surgery with CPB, tertiary care center in Shanghai, China
- Participants
- 59 children
- Comparison
- Dexmedetomidine (DEX) vs normal saline for 10 minutes after anesthetic induction
Methodological detailssingle-centre
- Single-centre
Primary result
As reported in the abstract
CVR-CO2
- CVR-CO2 comparable between the two groups
- DEX vs Control: P = 0.402
Further findings
| Outcome | P value |
|---|---|
| PI, RI, Vmean, ScrO2DEX vs Control · PI | P = 0.203 |
| PI, RI, Vmean, ScrO2DEX vs Control · RI | P = 0.290 |
| PI, RI, Vmean, ScrO2DEX vs Control · Vmean | P = 0.290 |
| PI, RI, Vmean, ScrO2DEX vs Control · ScrO2 | P = 0.426 |
| Hemodynamics (HR, MAP)DEX vs Control · HR | P = 0.522 |
| Hemodynamics (HR, MAP)DEX vs Control · MAP | P = 0.236 |
Pulsatility index (PI), resistance index (RI), Vmean, ScrO2
- Comparable between the two groups
Hemodynamics (HR, mean arterial pressure (MAP))
- Comparable between the two groups
Change before vs after surgery (within group)
- Control: PI, RI and HR significantly differed before and after surgery
- DEX: RI, Vmean, ScrO2 and HR significantly differed before and after surgery
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Effect of Dexmedetomidine on Cerebrovascular Carbon Dioxide Reactivity During Pediatric Cardiac Surgery With Cardiopulmonary Bypass. J Cardiothorac Vasc Anesth. Published 3 March 2025. doi:10.
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