Pediatric anesthesia & critical care
Effects of Dexmedetomidine on Brain and Inflammatory Outcomes In Pediatric Cardiac Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors' conclusion
The authors' findings support the effect of dexmedetomidine on reductions in brain markers among children who undergo cardiac surgery.
Study context
- Population
- Children aged <18 years undergoing congenital heart surgery under anaesthesia
- Participants
- 579 children · 7 randomized controlled trials (RCTs)
- Comparison
- Intravenous dexmedetomidine vs normal saline
- Outcome
- Brain markers (NSE, S-100β) and inflammatory markers (interleukin-6, TNF-α, NF-κB)
- Follow-up
- During and after cardiac surgery
Methodological detailsrandom-effect models, Cochrane revised risk-of-bias tool
- Random-effect models
- Cochrane revised risk-of-bias tool
Pooled result
As reported in the abstract
Dexmedetomidine vs Normal salineEstimate (95% CI)
Within 24 hours; 5 treatment groups in 3 RCTs, 260 children
SMD (NSE) −0.54(−0.96 to −0.12)
4 treatment groups in 2 RCTs, 190 children
SMD (interleukin-6) −1.55(−2.82 to −0.27)
Similar levels; 4 treatment groups in 2 RCTs, 190 children
SMD (TNF-α) −0.07(−0.33 to 0.19)
Similar levels; 2 treatment groups in 1 RCT, 90 children
SMD (NF-κB) −0.27(−0.62 to 0.09)
- Within 24 hours; 5 treatment groups in 3 RCTs, 260 children
- SMD (S-100β) −0.85 (95% CI −1.67 to −0.04)
Original publication
Effects of Dexmedetomidine on Brain and Inflammatory Outcomes In Pediatric Cardiac Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Cardiothorac Vasc Anesth. Published 16 February 2023. doi:10.
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