Comparison of cooled versus conventional radiofrequency treatment of the genicular nerves for chronic knee pain: a multicenter non-inferiority randomized pilot trial (COCOGEN trial)
Authors' conclusion
This pilot study did not demonstrate statistically significant differences in the proportion of patients experiencing ≥50% pain reduction between techniques. The non-inferiority analysis was inconclusive.
Study context
- Population
- Chronic knee pain patients with osteoarthritis or persistent postsurgical pain after total knee arthroplasty47 completed 3-month follow-up
- Participants
- 49 patients
- Comparison
- Conventional vs cooled radiofrequency (RF) treatment of the genicular nerves
- Conventional RFn = 23
- Cooled RFn = 24reference
- Primary endpoint
- Proportion of patients with ≥50% pain reduction
- Follow-up
- 3 months postintervention
Methodological detailsdouble blind, non-inferiority, pilot, multicenter
- Double blind
- Non-inferiority
- Pilot
- Multicenter
Primary result
As reported in the abstract
3 months
Secondary outcomes
Knee pain, functionality, quality of life, emotional health · up to 6 months
- No statistically significant difference between secondary outcomes
Safety
- No serious adverse events
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Comparison of cooled versus conventional radiofrequency treatment of the genicular nerves for chronic knee pain: a multicenter non-inferiority randomized pilot trial (COCOGEN trial). Reg Anesth Pain Med. Published 18 January 2023. doi:10.
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