Perioperative Analgesic Interventions for Reduction of Persistent Postsurgical Pain After Total Hip and Knee Arthroplasty: A Systematic Review and Meta-analysis
Pooled resultResult — go to the resultMean difference −4.9 mm 95% CI −6.5 to −3.4Authors' conclusion
We found no perioperative analgesic interventions that reduced pain 3 to 24 months after total hip or knee arthroplasty for osteoarthritis.
Study context
- Population
- Patients with osteoarthritis undergoing total hip or knee arthroplasty49 trials · 68 intervention arms
- Comparison
- Perioperative analgesic interventions vs control
- Outcome
- Pain score, at rest and during movement separately
- Follow-up
- 3 to 24 months after surgery
Methodological detailstrial sequential analysis, worst-best and best-worst case analyses, Cochrane Risk of Bias 2
- Trial sequential analysis
- Worst-best and best-worst case analyses
- Cochrane Risk of Bias 2
Pooled result
As reported in the abstract
3 to 24 months
Mean difference
−4.9 mm
95% CI −6.5 to −3.4
Duloxetine vs Placebo
mean difference −4.9 mm (95% CI −6.5 to −3.4)
Original publication
Perioperative Analgesic Interventions for Reduction of Persistent Postsurgical Pain After Total Hip and Knee Arthroplasty: A Systematic Review and Meta-analysis. Anesth Analg. Published 17 October 2024. doi:10.
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