Opioid consumption and non‐opioid multimodal analgesic treatment in pain management trials after hip and knee arthroplasties: A meta‐epidemiological study
Authors' conclusion
Post-operative 0-24 h morphine consumption was median 21-22 mg.
Study context
- Population
- Trials of analgesic interventions for post-operative pain in adults undergoing total hip or knee arthroplastytrials
- Participants
- 570 trials
- Comparison
- Hip arthroplasty trials vs Knee arthroplasty trials
- Outcome
- Aggregated median post-operative opioid consumption
- Follow-up
- Median 0-24 h
Methodological detailssystematic literature search, meta-regression, Search 7 January 2020 in Cochrane CENTRAL, PubMed and EMBASE; 14,200 records screened
- Systematic literature search
- Meta-regression
- Search 7 January 2020 in Cochrane CENTRAL, PubMed and EMBASE; 14,200 records screened
Main finding
As reported in the abstract
Median 0-24 h opioid consumption
Further findings
Opioid consumption vs publication year
- Meta-regression: no overall linear correlation between opioid consumption and publication year
Use of multimodal non-opioid analgesia
- Use increased over time; trials published 2010–2020 administering two or more non-opioid analgesics
- 48%
Number of non-opioid analgesics and opioid consumption
- More non-opioid analgesics associated with lower opioid consumption in intervention groups
Original publication
Opioid consumption and non‐opioid multimodal analgesic treatment in pain management trials after hip and knee arthroplasties: A meta‐epidemiological study. Acta Anaesthesiol Scand. Published 21 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →