Analgesic efficacy and functional outcomes of 10 versus 20 mL bupivacaine for popliteal plexus block after total knee arthroplasty: a randomized clinical trial
Primary resultResult — go to the resultMedian difference 0 mg 95% CI −10 to 5Authors' conclusion
Use of 20 mL of local anesthetic for the popliteal plexus block as part of a multimodal analgesic regimen after total knee arthroplasty does not provide superior analgesic efficacy or improved functional outcomes compared with 10 mL.
Study context
- Population
- Adults undergoing primary unilateral total knee arthroplasty under spinal anaesthesia, with standardised multimodal analgesia incl. femoral triangle block
- Participants
- 120 adults
- Comparison
- Popliteal plexus block with 20 mL vs 10 mL bupivacaine 5 mg/mL
- Primary endpoint
- Postoperative opioid consumption (oral MME)
- Follow-up
- 24 hours
Methodological detailssingle-centre, blinded
- Single-centre
- Blinded
Primary result
As reported in the abstract
Median difference
0 mg
95% CI −10 to 5
P = 0.6
By group
20 mL vs 10 mL
median difference 0 mg (95% CI −10 to 5); P = 0.6
Secondary outcomes
Opioid-free analgesia, pain at rest or during ambulation, ambulation with crutches, motor impairment, QoR-15
- No statistically significant or clinically relevant differences between groups
Original publication
Analgesic efficacy and functional outcomes of 10 versus 20 mL bupivacaine for popliteal plexus block after total knee arthroplasty: a randomized clinical trial. Reg Anesth Pain Med. Published 18 March 2026. doi:10.
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