Analgesic efficacy of popliteal plexus block versus infiltration between the popliteal artery and capsule of the posterior knee block combined with femoral triangle block after total knee arthroplasty: a randomized non-inferiority trial and cadaveric evaluation
Primary resultResult — go to the resultDifference 4.7 90% CI −5.6 to 14.9Authors' conclusion
Compared with the IPACK block, popliteal plexus block provides non-inferior posterior knee analgesia following TKA while maintaining ankle muscle strength, with the additional advantage of having a shorter block performance time.
Study context
- Population
- Participants undergoing elective total knee arthroplasty (TKA)plus 7 cadaveric legs
- Participants
- 86 participants
- Comparison
- IPACK vs Popliteal plexus block
- Primary endpoint
- Moderate-to-severe posterior knee pain
- Follow-up
- Eight postoperative hours
Methodological detailsnon-inferiority, cadaveric evaluation
- Non-inferiority
- Cadaveric evaluation
Primary result
As reported in the abstract
Difference
4.7
90% CI −5.6 to 14.9
P < 0.001
IPACK vs Popliteal plexus block
difference 4.7 (90% CI −5.6 to 14.9); P < 0.001
Non-inferiority margin 17 as printed, not drawn
Secondary outcomes
Block performance time
P < 0.0001
Preservation of motor function
- No significant difference
Injectate spread in popliteal plexus block (cadaveric legs)
- Posterior articular branches stained in all cadaveric specimens
Original publication
Analgesic efficacy of popliteal plexus block versus infiltration between the popliteal artery and capsule of the posterior knee block combined with femoral triangle block after total knee arthroplasty: a randomized non-inferiority trial and cadaveric evaluation. Reg Anesth Pain Med. Published 12 August 2025. doi:10.
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