Respiratory failure & ventilation
Comparison of the efficacy and comfort of high-flow nasal cannula with different initial flow settings in patients with acute hypoxemic respiratory failure: a systematic review and network meta-analysis
Pooled result · IntubationResult — go to the resultOdds ratio 0.72 95% CrI 0.56–0.93Authors' conclusion
The high initial flow settings (50-60 L/min) performed better in decreasing the occurrence of intubation and mortality, albeit with poor comfort scores.
Study context
- Population
- Patients with acute hypoxemic respiratory failure (AHRF)
- Participants
- 5,774 patients · 23 randomized controlled trials (RCTs)
- Comparison
- High-flow nasal cannula (HFNC) with different initial flow settings vs NIV
- Outcome
- Intubation
- Follow-up
- Day 28
Methodological detailsBayesian framework
- Bayesian framework
Pooled result
As reported in the abstract
Odds ratio
0.72
95% CrI 0.56–0.93
HFNC_High vs NIV
OR 0.72 (95% CrI 0.56–0.93)
- HFNC_High highest probability of being best in reducing intubation rates
- 73.04%
Further pooled results
| Outcome | OR (95% CrI) | |
|---|---|---|
| Short-term mortalityHFNC_High vs NIV · moderate quality evidence | 0.81 (0.69–0.96) | |
| 0.512Odds ratio (log scale) |
| Outcome | MD (95% CrI) | |
|---|---|---|
| Comfort scoreHFNC_Low vs HFNC_Mod | - 1.98 (−3.98 to 0.01) | |
| −4−202Difference (linear scale) |
- Short-term mortality — HFNC_High highest probability of being best in reducing short-term mortality
- 82.74%
- Short-term mortality: 95% CrI
- Comfort score: very low quality evidence; no statistically significant difference
- Comfort score: 95% CrI
Long-term mortality
- HFNC_High highest probability of being best in reducing long-term mortality
- 67.08%
Comfort score
- SUCRA: HFNC_Low highest probability of being best for comfort scores
Original publication
Comparison of the efficacy and comfort of high-flow nasal cannula with different initial flow settings in patients with acute hypoxemic respiratory failure: a systematic review and network meta-analysis. J Intensive Care. Published 10 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →