Pediatric anesthesia & critical care
Comparison of the efficacy of intranasal atomised dexmedetomidine versus intranasal atomised ketamine as a premedication for sedation and anxiolysis in children undergoing spinal dysraphism surgery: A randomized controlled trial
Authors' conclusion
Intranasal atomised dexmedetomidine produces greater sedation as compared to intranasal atomised ketamine with comparable ease of parental separation, venous cannulation and mask acceptance with no adverse effects.
Study context
- Population
- Children aged 1 to 10 years undergoing spinal dysraphism surgery, tertiary teaching hospital
- Participants
- 64 children
- Comparison
- Group D vs Group K
- Group Dn = 32
- Group Kn = 32reference
- Primary endpoint
- Level of sedation (University of Michigan Sedation Score, University of Michigan Sedation Score (UMSS))
Methodological detailsprospective, double-blind
- Prospective
- Double-blind
Primary result
Sedation (UMSS) · 20 min
Difference
−0.406
95% CI −0.621 to −0.191
P = 0.0001
By group
Group D
1.55
± 0.51
Group K
1.13
± 0.34
Group D vs Group K
difference −0.406 (95% CI −0.621 to −0.191); P = 0.0001
As reported in the abstract
Secondary outcomes
| Outcome | Group D | Group K | Difference (95% CI) | P value | |
|---|---|---|---|---|---|
| Sedation (UMSS) · 30 min | 2.32 ± 0.6 | 1.94 ± 0.50 | −0.374 (−0.650 to −0.100) | P = 0.007 | |
| −1−0.500.5Difference (linear scale) |
| Outcome | P value |
|---|---|
| Ease of parental separation, venous cannulation and mask acceptanceParental separation | P = 0.83 |
| Ease of parental separation, venous cannulation and mask acceptanceVenous cannulation | 0.418 |
| Ease of parental separation, venous cannulation and mask acceptanceMask acceptance | 0.100 |
Ease of parental separation, venous cannulation and mask acceptance
- Comparable in both groups
Heart rate · 10, 20 and 30 min post-drug administration
- Lower in Group D but clinically insignificant
Emergence agitation and time to discharge
- Similar in both groups
Safety
- No adverse events reported
Original publication
Comparison of the efficacy of intranasal atomised dexmedetomidine versus intranasal atomised ketamine as a premedication for sedation and anxiolysis in children undergoing spinal dysraphism surgery: A randomized controlled trial. Eur J Anaesthesiol. Published 14 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →