Pediatric anesthesia & critical care
Comparison of plasma concentration and sedative effect of sublingual and intranasal dexmedetomidine in children: A double‐blind randomised controlled study
Authors' conclusion
Intranasal 2 μg/kg dexmedetomidine resulted in significantly higher peak plasma concentration and time to reach peak plasma concentration than sublingual wafers. Sublingual and intranasal dexmedetomidine resulted in comparable sedation, parental separation and mask acceptance.
Study context
- Population
- Children 2–12 years, 10–30 kg, scheduled for surgery
- Participants
- 30 children
- Comparison
- Sublingual vs intranasal dexmedetomidine 2 μg/kg premedication
- Primary endpoint
- Peak plasma concentration, time to peak plasma concentration and AUC of dexmedetomidine
Methodological detailsdouble-blind
- Double-blind
Primary result
As reported in the abstract
Peak plasma concentration, time to peak and AUC
| Group | Value | Time to peak, median (IQR), minutes | AUC, median (IQR), ng/mL.h |
|---|---|---|---|
| Group N | median 0.764 (IQR 0.650–0.820) ng/mL | 45 [45-120] | 1.062 [0.848-1.20] |
| Group S | median 0.593 (IQR 0.364–0.754) ng/mL | 60 [45-60] | 0.866 [0.520-1.05] |
Value
Group Nmedian 0.764 (IQR 0.650–0.820) ng/mL
Group Smedian 0.593 (IQR 0.364–0.754) ng/mL
Time to peak, median (IQR), minutes
Group N45 [45-120]
Group S60 [45-60]
AUC, median (IQR), ng/mL.h
Group N1.062 [0.848-1.20]
Group S0.866 [0.520-1.05]
- Group N vs Group S: P = 0.014
- Group N vs Group S: P = 0.814
- Group N vs Group S: P = 0.031
Further findings
| Outcome | P value |
|---|---|
| Plasma concentration at 30 and 45 minSignificantly higher in Group N | P < 0.05 |
Sedation, parental separation anxiety, mask acceptance, recovery, analgesic requirements
- Comparable sedation at 25 min in both groups; parental separation anxiety, mask acceptance, recovery and analgesic requirements comparable
Safety
- No child required treatment for decreased heart rate
Original publication
Comparison of plasma concentration and sedative effect of sublingual and intranasal dexmedetomidine in children: A double‐blind randomised controlled study. Acta Anaesthesiol Scand. Published 29 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →