Comparison of intrathecal morphine, lateral quadratus lumborum block, and their combination for analgesia and quality of recovery after Caesarean delivery: a randomised, double-blind, two-centre clinical trial
Primary result · QoR-40 at 24 hResult — go to the resultMean difference −0.9 90% CI −0.9 to 13.5Authors' conclusion
Noninferiority of QLB vs ITM for QoR-40 at 24 h was inconclusive. However, QLB reduced early resting pain vs ITM, whereas ITM+QLB further reduced early resting and coughing pain and worst pain at 24 h vs ITM alone.
Study context
- Population
- Women undergoing Caesarean delivery under spinal anaesthesiaanalysed
- Participants
- Fifty-eight women
- Comparison
- Lateral quadratus lumborum block (QLB) vs intrathecal morphine (ITM) vs ITM+QLB
- Primary endpoint
- QoR-40 score
- Follow-up
- 24 h
Methodological detailsdouble-blind, placebo-controlled, two-centre, noninferiority testing
- Double-blind
- Placebo-controlled
- Two-centre
- Noninferiority testing
Primary result
QoR-40 at 24 h
Mean difference
−0.9
90% CI −0.9 to 13.5
ITM vs QLB
mean difference −0.9 (90% CI −0.9 to 13.5)
As reported in the abstract
Secondary outcomes
| Outcome | Mean difference | P value | |
|---|---|---|---|
| Resting pain score, QLB vs ITM · 6 hQLB reduced pain | 2.9 (95% CI 1.3–4.5) | P < 0.001 | |
| Pain scores, ITM+QLB vs ITMITM+QLB vs ITM · resting pain at 6 h, reduced with ITM+QLB | 3.3 (CI 1.9–4.8) | P < 0.001 | |
| Pain scores, ITM+QLB vs ITMITM+QLB vs ITM · coughing pain at 6 h, reduced with ITM+QLB | 3.0 (CI 1.4–4.7) | P < 0.001 | |
| Pain scores, ITM+QLB vs ITMITM+QLB vs ITM · worst pain at 24 h, reduced with ITM+QLB | 1.8 (CI 0.6–3.1) | P = 0.006 | |
| −20246Difference (linear scale) |
Oxycodone consumption
- Did not differ between groups
Safety
Nausea or vomiting
- Did not differ between groups
Pruritus
- More frequent with QLB and ITM+QLB vs ITM alone, predominantly mild
Original publication
Comparison of intrathecal morphine, lateral quadratus lumborum block, and their combination for analgesia and quality of recovery after Caesarean delivery: a randomised, double-blind, two-centre clinical trial. Br J Anaesth. Published 10 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →