Pediatric anesthesia & critical care
Comparison of analgesic efficacy and safety of caudal dexmedetomidine versus intranasal dexmedetomidine in paediatric infraumbilical surgeries: A randomised controlled trial
Authors' conclusion
Intranasal dexmedetomidine can be considered a feasible analgesic adjunct to a single-injection caudal block in children undergoing infraumbilical surgeries associated with a smooth recovery profile and no associated adverse effects.
Study context
- Population
- Children aged 1 to 8 years undergoing infraumbilical surgeries under GA with caudal analgesia, tertiary care hospital
- Participants
- 64 children
- Comparison
- Caudal vs Intranasal
- Primary endpoint
- Duration of postoperative analgesia
Methodological detailsnoninferiority
- Noninferiority
Primary result
As reported in the abstract
P = 0.422
Further findings
Intra-operative heart rate
- Comparable decrease in both groups
Sedation
- Caudal more sedated until 2 h postsurgery; equivalent thereafter
Postoperative pain scores, peri-operative analgesic consumption, emergence delirium
- Comparable between groups
Safety
Events
| Outcome | Caudal | Intranasal | P value |
|---|---|---|---|
| Intra-operative hypotension episodesMore episodes in caudal group; no vasopressors needed | P = 0.016 | ||
| Adverse events · 24 h postoperatively | 0 | 0 |
Original publication
Comparison of analgesic efficacy and safety of caudal dexmedetomidine versus intranasal dexmedetomidine in paediatric infraumbilical surgeries: A randomised controlled trial. Eur J Anaesthesiol. Published 27 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →