Neuroanesthesia & neurocritical care
Comparison of Esketamine and Propofol for Prehospital Emergency Anaesthesia in Patients With Traumatic Brain Injury—A Retrospective Observational Study
Main findingResult — go to the resultOdds ratio 0.598 95% CI 0.281–1.272Authors' conclusion
In this study, we found no significant difference in mortality, but we found significant differences in the haemodynamic responses between esketamine and propofol, with a slightly favourable haemodynamic profile in patients treated with esketamine.
Study context
- Population
- TBI patients intubated by a single Finnish helicopter emergency medical services (HEMS) unit, January 2014 to December 2021
- Participants
- 366 patients
- Exposure
- Esketamine vs propofol for prehospital emergency anaesthesia induction
- Esketaminen = 301
- Propofoln = 65reference
- Outcome
- Mortality before hospital discharge
Methodological detailssingle HEMS unit, logistic regression for confounders
- Single HEMS unit
- Logistic regression for confounders
Main finding
As reported in the abstract
Odds ratio
0.598
95% CI 0.281–1.272
Esketamine vs Propofol
OR 0.598 (95% CI 0.281–1.272)
Observational data: associations, not effects.
Secondary outcomes
Absolute change, mmHg
| Outcome | Esketamine | Propofol | Estimate |
|---|---|---|---|
| Decrease in BP after intubationGreater decrease in propofol group | −12.4 | −37.3 | (95% CI −38 to −15) |
Decrease in BP after intubation
- Similar postintubation physiology in both groups (higher initial BP with propofol)
Original publication
Comparison of Esketamine and Propofol for Prehospital Emergency Anaesthesia in Patients With Traumatic Brain Injury—A Retrospective Observational Study. Acta Anaesthesiol Scand. Published 22 October 2025. doi:10.
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