Cardiac arrest & resuscitation
Comparison of four clinical risk scores in comatose patients after out-of-hospital cardiac arrest
Authors' conclusion
The TTM-, MIRACLE2- and CAHP-scores are all capable of providing objective risk estimates accurate enough to be used as part of a holistic patient assessment after OHCA of a suspected cardiac origin.
Study context
- Population
- Comatose patients after Out-of-hospital Cardiac Arrest (OHCA) (TTM2 trial)
- Participants
- 1,829 patients
- Comparison
- MIRACLE2, Target Temperature Management (TTM), Cardiac Arrest Hospital Prognosis (CAHP) and OHCA risk scores
- Primary endpoint
- Discrimination (AUROC) for poor functional outcome or death (modified Rankin Scale 4-6)
- Follow-up
- 6 months after OHCA
Methodological detailspost-hoc analysis, multiple imputation for missing data
- Post-hoc analysis
- Multiple imputation for missing data
Primary result
As reported in the abstract
AUROC for poor functional outcome or death · 6 months
| Group | Pooled AUROC |
|---|---|
| MIRACLE2 | 0.810 (95% CI 0.790-0.828) |
| TTM | 0.835 (95% CI 0.816-0.852) |
| CAHP | 0.820 (95% CI 0.800-0.839) |
| OHCA | 0.770 (95% CI 0.748-0.791) |
Pooled AUROC
MIRACLE20.810 (95% CI 0.790-0.828)
TTM0.835 (95% CI 0.816-0.852)
CAHP0.820 (95% CI 0.800-0.839)
OHCA0.770 (95% CI 0.748-0.791)
Further findings
Sensitivity at cut-offs for specificity >95%
- Sensitivities <40% for all four scores at specificities >95%
Original publication
Comparison of four clinical risk scores in comatose patients after out-of-hospital cardiac arrest. Resuscitation. Published 25 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →