Pediatric anesthesia & critical care

Comparison of gastric emptying time between breast‐fed and formula milk‐fed infants less than 6 months old, using gastric ultrasound—An observational study

Paediatr AnaesthPublished Prospective observational study

Authors' conclusion

In our series, the gastric emptying times in breast-fed and formula-fed infants less than 6 months old were similar.

Study context

Population
Infants less than 6 months old, tertiary care center in India
Participants
52 participants
Exposure
Breast-fed vs formula milk-fed infants
  • Breast-fedn = 26reference
  • Formula milk-fedn = 26
Outcome
Gastric emptying time (bull's eye appearance of antrum or antral cross-sectional area <3.07 cm²) by gastric ultrasound
Methodological detailssingle-centre, gastric ultrasound
  • Single-centre
  • Gastric ultrasound

Main finding

As reported in the abstract

Gastric emptying time (Schmitz's formula)
GroupValue95% CIRange
Breast-fedmean 0.35 (SD 0.68) h0.35 ± 0.1850.165-0.535
Formula milk-fedmean 0.35 (SD 0.69) h0.35 ± 0.1880.162-0.538

Value

Breast-fedmean 0.35 (SD 0.68) h
Formula milk-fedmean 0.35 (SD 0.69) h

95% CI

Breast-fed0.35 ± 0.185
Formula milk-fed0.35 ± 0.188

Range

Breast-fed0.165-0.535
Formula milk-fed0.162-0.538
  • Formula milk-fed vs Breast-fed: P = 0.73 — neither clinically nor statistically different

Observational data: associations, not effects.

Further findings

OutcomeBreast-fedP value
Gastric emptying time, Spencer's formulaFormula-fed vs Breast-fed · neither clinically nor statistically differentmean 0.12 (SD 0.33) hP = 0.13
95% CI0.12 ± 0.09
Range0.03-0.21
Antral cross-sectional area >3.07 cm² (aspiration risk cut-off) beyond 1 h53.84%
Antral cross-sectional area >3.07 cm² beyond 3 h0 events
  • Gastric emptying time, Spencer's formula: Formula-fed mean 0.04 (SD 0.20) h · 95% CI 0.04 ± 0.05 · range −0.01 to 0.09
  • Antral cross-sectional area >3.07 cm² (aspiration risk cut-off) beyond 1 h: Formula-fed 65.38%
  • Antral cross-sectional area >3.07 cm² beyond 3 h: Formula-fed 3.84%

Original publication

Comparison of gastric emptying time between breast‐fed and formula milk‐fed infants less than 6 months old, using gastric ultrasound—An observational study. Paediatr Anaesth. Published 7 February 2024. doi:10.1111/pan.14841

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