Paediatric anaesthesia & critical care
Comparison of Methylprednisolone and Dexamethasone in Their Interaction With Sugammadex in Pediatric Patients: A Randomized Controlled Trial
Authors' conclusion
At clinically equivalent glucocorticoid doses, methylprednisolone was associated with longer sugammadex-mediated reversal and extubation time than dexamethasone and control, while postoperative pain, nausea scores, and adverse event rates were comparable between the groups. These findings indicate that the corticosteroid selected for peri-operative use may influence the efficacy of sugammadex-mediated reversal in children.
Study context
- Population
- Children undergoing adenotonsillar surgerychildren randomized
- Participants
- Sixty children
- Comparison
- Methylprednisolone 1 mg kg-1, dexamethasone 0.2 mg kg-1, or no corticosteroid (control)
- Primary endpoint
- Rocuronium reversal time: interval from the sugammadex bolus at train of four count = 2 to a normalized train of four ratio of 0.9
Primary result
As reported in the abstract
P < 0.001
Secondary outcomes
Extubation time
- Extubation time showed a similar pattern
Postoperative nausea-vomiting and pain scores
- Did not differ significantly between groups
Safety
Overall incidence of adverse events
- Did not differ significantly between groups
Original publication
Comparison of Methylprednisolone and Dexamethasone in Their Interaction With Sugammadex in Pediatric Patients: A Randomized Controlled Trial. Paediatr Anaesth. Published 3 October 2026. doi:10.
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