Pediatric anesthesia & critical care
The effect of methylprednisolone on the reversal time of rocuronium by sugammadex in the paediatric patient group: A randomised controlled trial
Primary resultResult — go to the resultMean difference 34.5 s 95% CI 27.3–41.6Authors' conclusion
Although methylprednisolone administration resulted in a significantly prolonged reversal of rocuronium-induced neuromuscular block by sugammadex and subsequent delayed extubation, the clinical importance of this interaction is minor.
Study context
- Population
- Paediatric patients undergoing elective adenoidectomy and/or tonsillectomy, Turkish tertiary care centre, September 2024 to January 2025
- Comparison
- M vs C
- Primary endpoint
- Reversal time of rocuronium by sugammadex 2 mg kg −1: from sugammadex at train of four (TOF) count = 2 to TOF ratio ≥0.9 of baseline
Methodological detailssingle centre, double blinded
- Single centre
- Double blinded
Primary result
As reported in the abstract
Mean difference
34.5 s
95% CI 27.3–41.6
P < 0.001
By group
M vs C
mean difference 34.5 s (95% CI 27.3–41.6); P < 0.001
Secondary outcomes
| Outcome | M | C | Difference (s) (95% CI) | P value | |
|---|---|---|---|---|---|
| Extubation time (sugammadex at TOF count = 2 to extubation) | 426.8 ± 134.4 s | 331.3 ± 129.0 s | 95.5 (36.8–154.2) | P = 0.002 | |
| −1000100200Difference, s (linear scale) |
Postoperative pain and PONV scores
- No significant differences
Safety
Adverse events (stridor, hoarseness, severe cough, desaturation)
- No significant difference in frequency
Original publication
The effect of methylprednisolone on the reversal time of rocuronium by sugammadex in the paediatric patient group: A randomised controlled trial. Eur J Anaesthesiol. Published 16 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →