Perioperative medicine & outcomes
Comparison of midazolam and dexmedetomidine on postoperative delirium in older patients undergoing total knee replacement under spinal anesthesia
Authors' conclusion
Dexmedetomidine significantly reduced the incidence of POD and improved sedation quality compared to midazolam.
Study context
- Population
- Patients aged ≥65 years undergoing total knee arthroplasty under spinal anaesthesia
- Participants
- 175 patients
- Comparison
- Dexmedetomidine vs midazolam for intraoperative sedation
- Primary endpoint
- Incidence of postoperative delirium (POD) (confusion assessment method)
- Follow-up
- 5 postoperative days
Methodological detailsprospective, double-blind, parallel group
- Prospective
- Double-blind
- Parallel group
Primary result
As reported in the abstract
P = 0.045
Secondary outcomes
| Outcome | P value |
|---|---|
| Sedation qualitySuperior with dexmedetomidine | P = 0.007 |
| Sedation failureLower with dexmedetomidine | P = 0.018 |
Postoperative pain intensity
- Comparable between the two groups
Safety
Complication rates
- Comparable between the two groups
Original publication
Comparison of midazolam and dexmedetomidine on postoperative delirium in older patients undergoing total knee replacement under spinal anesthesia. Perioper Med (Lond). Published 29 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →