Comparison of the effects of dexmedetomidine and propofol on the cardiovascular autonomic nervous system during spinal anesthesia: preliminary randomized controlled observational study
Authors' conclusion
Dexmedetomidine showed slower heart rate and higher blood pressure than propofol when combined with spinal anesthesia, however, dexmedetomidine and propofol exhibited similar trends in HRV dynamics.
Study context
- Population
- Patients aged 20–65 undergoing elective surgery under spinal anaesthesia
- Participants
- 59 patients
- Comparison
- Dexmedetomidine vs propofol sedation combined with spinal anaesthesia
- Primary endpoint
- Effect on autonomic nervous system: heart rate variability (HRV) and hemodynamic variables
- Follow-up
- T0 baseline; T1 10 min after spinal; T2 10 and T3 20 min after sedative
Methodological detailspreliminary
- Preliminary
Primary result
As reported in the abstract
Hemodynamic changes and HRV over time
- Significantly different hemodynamic changes over time between groups (time × group effect)
- P < 0.001
- Slower HR at T2 with dexmedetomidine vs propofol
- P = 0.001
- Higher BP at T2 and T3 with dexmedetomidine vs propofol
- P < 0.001
Original publication
Comparison of the effects of dexmedetomidine and propofol on the cardiovascular autonomic nervous system during spinal anesthesia: preliminary randomized controlled observational study. J Clin Monit Comput. Published 12 August 2023. doi:10.
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