Comparison of tramadol and lornoxicam for the prevention of postoperative catheter-related bladder discomfort: a randomized controlled trial
Authors' conclusion
Tramadol and lornoxicam administered intravenously at the end of the surgery were both effective in preventing the incidence and severity of CRBD after uterine surgery. However, tramadol increased the incidence of nausea compared with saline, but there was no difference between tramadol and lornoxicam.
Study context
- Population
- Patients aged 18–60 years, ASA 1–2, undergoing elective uterine surgery requiring intraoperative urinary catheterization
- Participants
- 120 patients
- Comparison
- IV tramadol vs lornoxicam vs normal saline at end of surgery
- Tn = 40
- Ln = 40
- Cn = 40reference
- Primary endpoint
- Incidence and severity of CRBD
- Follow-up
- 0, 1, 2, and 6 h after arrival at the PACU
Primary result
As reported in the abstract
- Incidence of CRBD significantly lower in T and L vs C at 1, 2, and 6 h after surgery
- Incidence of moderate to severe CRBD significantly lower in T and L vs C at 0, 1, and 2 h after surgery
- Severity of CRBD reduced in T and L vs C at most times after surgery
Safety
- Higher incidence of nausea in T vs C
- No differences in dizziness, drowsiness, or vomiting among the three groups
Original publication
Comparison of tramadol and lornoxicam for the prevention of postoperative catheter-related bladder discomfort: a randomized controlled trial. Perioper Med (Lond). Published 19 June 2023. doi:10.
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