Perioperative medicine & outcomes
Comparison of pre- and intra-operative analgesia of fascia Iliaca compartment block in reducing post-operative delirium of elderly patients following hip fractures: a retrospective study
Authors' conclusion
Compared with IO-FICB, PO-FICB may confer more targeted analgesia and is associated with a lower incidence of POD in elderly hip fracture patients.
Study context
- Population
- Elderly hip fracture patients, January 2015 to December 2020
- Participants
- 198 patients
- Exposure
- Preoperative vs intraoperative fascia iliaca compartment block
- PO-FICBn = 100
- IO-FICBn = 98reference
- Outcome
- POD incidence (Confusion Assessment Method, assessed daily)
- Follow-up
- 72 h
Main finding
As reported in the abstract
POD incidence
P = 0.0168
Observational data: associations, not effects.
Further findings
| Outcome | PO-FICB | IO-FICB | P value |
|---|---|---|---|
| MMSE score · Day 1All days 1-3 | 27.85 ± 1.923 | 25.80 ± 1.864 | P < 0.01 |
| MMSE score · Day 2All days 1-3 | 27.49 ± 2.807 | 25.73 ± 2.197 | P < 0.01 |
| MMSE score · Day 3All days 1-3 | 27.23 ± 1.698 | 22.57 ± 2.128 | P < 0.01 |
| VAS pain score · Day 1Days 1-2 | 1.58 ± 0.702 | 2.70 ± 0.659 | P < 0.0001 |
| VAS pain score · Day 2Days 1-2 | 2.26 ± 0.647 | 3.02 ± 0.853 | P < 0.0001 |
| VAS pain score · Day 3 | 2.40 ± 0.492 | 2.33 ± 0.620 | P = 0.068 |
| Inflammatory mediators (CRP, IL-1, IL-6, TNF-α) | all P < 0.05 |
Inflammatory mediators (CRP, IL-1, IL-6, TNF-α)
- Lower levels in the PO-FICB group
Severe complications or mortality · 12-month follow-up
- No severe complications or mortality observed
Original publication
Comparison of pre- and intra-operative analgesia of fascia Iliaca compartment block in reducing post-operative delirium of elderly patients following hip fractures: a retrospective study. Perioper Med (Lond). Published 18 July 2026. doi:10.
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