Complete versus culprit-lesion-only percutaneous coronary intervention after out-of-hospital cardiac arrest in patients with multivessel disease

Raone, L; Ferlini, M; Bongiorno, A; Bendotti, S; Currao, A; Primi, R; Fava, C; Dall'Oglio, L; Adamo, M; Ghiraldin, D; Marino, M; Baldo, A; Maffeo, D; Kajana, V; Affinito, S; Baldi, E; Luca, L; Savastano, S

doi:10.1016/j.resuscitation.2024.110471

Cardiac arrest & resuscitation

Complete versus culprit-lesion-only percutaneous coronary intervention after out-of-hospital cardiac arrest in patients with multivessel disease

ResuscitationPublished 27 Dec 2024Prospective observational study

Main finding · All-cause deathResultHazard ratio 0.29 95 % CI 0.09–0.98

Read the original article ↗PubMed

Cite

Authors' conclusion

Our findings suggest that a complete percutaneous coronary revascularization strategy is associated with improved one-year survival rates in patients with MVD resuscitated from OHCA.

Study context

Population: Out-of-hospital cardiac arrest (OHCA) survivors with multivessel CAD undergoing invasive coronary angiography, Lombardia CARe Registry, 2015–2022MVD among 538 with invasive coronary angiography (ICA)
Participants: 230 survivors

Exposure: Complete revascularization vs culprit-lesion-only PCI
Complete revascularizationn = 77
Culprit-lesion-onlyn = 152reference
Outcome: Death from any cause
Follow-up: 1 year

Methodological detailsmulticentre, registry-based (Lombardia CARe Registry), 8 centres in Northern Italy

Multicentre
Registry-based (Lombardia CARe Registry)
8 centres in Northern Italy

Main finding

All-cause death

Hazard ratio

0.29

95 % CI 0.09–0.98

P = 0.047

By group

Complete revascularization20.8 %

Culprit-lesion-only53.3 %

Complete revascularization vs Culprit-lesion-only

HR 0.29 (95 % CI 0.09–0.98); P = 0.047

As reported in the abstract

Observational data: associations, not effects.

Further findings

Outcome	← Lower risk with complete revascularization ←→ Higher risk with complete revascularization →	HR (95 % CI)	P value
Death from any cause or unfavorable neurological outcome · 1 yearMultivariable analysis	0.050.21520	0.23 (0.06–0.81)	P = 0.022
	0.050.21520Hazard ratio (log scale)

Outcome	Culprit-lesion-only	P value
Death from any cause or unfavorable neurological outcome · 1 yearUnadjusted	55.9 %	P < 0.001

Original publication

Complete versus culprit-lesion-only percutaneous coronary intervention after out-of-hospital cardiac arrest in patients with multivessel disease. Resuscitation. Published 27 December 2024. doi:10.1016/j.resuscitation.2024.110471

Read the original article ↗

Composed by AI from the published abstract and checked against it. How Briefs are made →