Comprehensive analysis of coagulation factor delivery strategies in a cohort of trauma patients
Authors' conclusion
The main hemostatic strategy for major bleeding combined the administration of both FFP and FC, favoring an early additional supply of fibrinogen. Compliance with the recommendations was low in SH and MT subgroups.
Study context
- Population
- Adult trauma patients admitted directly to French trauma centers, 2011–2019
- Participants
- 19,396 patients
- Exposure
- Severe hemorrhage (SH) vs massive transfusion (MT)
- SHn = 1,630
- MTn = 579
- Outcome
- Coagulation factor administration within first 24 hours
- Follow-up
- 24 hours
Methodological detailsmulticentre registry
- Multicentre registry
Main finding
As reported in the abstract
Coagulation factor administration within first 24 hours
FC
- Fresh frozen plasma (FFP), whole cohort
- 10%
- Fibrinogen concentrate (FC), whole cohort
- 8%
Observational data: associations, not effects.
Further findings
Per-patient compliance with recommendations
Co-administration of FFP and FC (SH)
- SH at 6 h
- 68%
- SH at 24 h
- 72%
Mortality by compliance
- Unadjusted mortality systematically lower in groups complying with recommendations
Original publication
Comprehensive analysis of coagulation factor delivery strategies in a cohort of trauma patients. Anaesth Crit Care Pain Med. Published 29 November 2022. doi:10.
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