Paediatric anaesthesia & critical care
Conservative versus liberal oxygenation targets in critically ill children (Oxy-PICU): a UK multicentre, open, parallel-group, randomised clinical trial
An erratum to this article was published (Lancet, 27 Jan 2024 ↗)
Authors' conclusion
Among invasively ventilated children who were admitted as an emergency to a PICU receiving supplemental oxygen, a conservative oxygenation target resulted in a small, but significant, greater probability of a better outcome in terms of duration of organ support at 30 days or death when compared with a liberal oxygenation target.
Study context
- Population
- Children >38 weeks corrected gestational age and <16 years admitted as an emergency to 15 UK paediatric intensive care units (PICUs), receiving invasive ventilation and supplemental oxygen1,872 (92%) with consent analysed
- Participants
- 2,040 children
- Comparison
- Conservative vs liberal oxygenation targets
- Conservativen = 939
- Liberaln = 933reference
- Primary endpoint
- Duration of organ support (rank-based; death on or before day 30 as worst outcome); effect estimate probabilistic index (>0.5 favours conservative)
- Follow-up
- 30 days
Methodological detailspragmatic, multicentre, open-label, parallel-group, 15 UK PICUs, Sept 1, 2020, to May 15, 2022
- Pragmatic
- Multicentre
- Open-label
- Parallel-group
- 15 UK PICUs, Sept 1, 2020, to May 15, 2022
Primary result
As reported in the abstract
Conservative vs LiberalAdjusted odds ratio (95% CI)
Conservative
0.84(0.72–0.99)
- Wilcoxon rank-sum test
- probabilistic index 0.53 (95% CI 0.50–0.55); P = 0.04
Safety
Prespecified adverse events
Original publication
Conservative versus liberal oxygenation targets in critically ill children (Oxy-PICU): a UK multicentre, open, parallel-group, randomised clinical trial. Lancet. Published 1 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →