Pediatric anesthesia & critical care
The rapid detection of respiratory pathogens in critically ill children
Authors' conclusion
TAC is a reliable and rapid adjunct diagnostic approach for LRTI in critically ill children, with the potential to aid early rationalisation of antimicrobial therapy.
Study context
- Population
- Mechanically ventilated children (> 37/40 weeks corrected gestation to 18 years) with suspected community acquired or ventilator-associated lower respiratory tract infection (LRTI), paediatric intensive care units (PICU)
- Participants
- 100 vs 91
- Comparison
- TaqMan Array Card (TAC) vs routine microbiology testing
- TACn = 100
- Culturen = 91reference
- Outcome
- Sensitivity and specificity of TAC, and time to result
Methodological detailssingle-centre, prospective, observational cohort
- Single-centre
- Prospective
- Observational cohort
Performance
As reported in the abstract
| Test or model | Value | Sensitivity | Specificity | Positive result | Negative result |
|---|---|---|---|---|---|
| TAC | 89.5% (confidence interval (CI95) 66.9-98.7) | 97.9% (CI95 97.2-98.5) | |||
| TAC | median 25.8 (IQR 9.1–29.8) h | ||||
| Culture | median 110.4 (IQR 85.2–141.6) h | 110.4 h | |||
| Culture | median 69.4 (IQR 52.8–78.6) h | 69.4 h |
Value
TAC— not stated in the abstract
TACmedian 25.8 (IQR 9.1–29.8) h
Culturemedian 110.4 (IQR 85.2–141.6) h
Culturemedian 69.4 (IQR 52.8–78.6) h
Sensitivity
TAC89.5% (CI95 66.9-98.7)
TAC— not stated in the abstract
Culture— not stated in the abstract
Culture— not stated in the abstract
Specificity
TAC97.9% (CI95 97.2-98.5)
TAC— not stated in the abstract
Culture— not stated in the abstract
Culture— not stated in the abstract
Positive result
TAC— not stated in the abstract
TAC— not stated in the abstract
Culture110.4 h
Culture— not stated in the abstract
Negative result
TAC— not stated in the abstract
TAC— not stated in the abstract
Culture— not stated in the abstract
Culture69.4 h
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
The rapid detection of respiratory pathogens in critically ill children. Crit Care. Published 10 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →