INHALE WP3, a multicentre, open-label, pragmatic randomised controlled trial assessing the impact of rapid, ICU-based, syndromic PCR, versus standard-of-care on antibiotic stewardship and clinical outcomes in hospital-acquired and ventilator-associated pneumonia
Authors' conclusion
In-ICU PCR for pathogens resulted in improved antibiotic stewardship. However, non-inferiority was not demonstrated for cure of pneumonia at 14 days.
Study context
- Population
- Adults and children with suspected HAP and VAP at 14 ICUs453 adults and 92 children analysed
- Participants
- 554 participants
- Comparison
- Intervention vs Standard of care
- Primary endpoint
- Co-primary: superiority in antibiotic stewardship at 24 h and non-inferiority in clinical cure of pneumonia 14 days post-randomisation
- Follow-up
- 24 h; 14 days
Methodological detailspragmatic, multicentre, open-label, non-inferiority (co-primary), Recruited 5th July 2019 to 18th August 2021, with COVID-enforced pause 16th March 2020 to 9th July 2020
- Pragmatic
- Multicentre
- Open-label
- Non-inferiority (co-primary)
- Recruited 5th July 2019 to 18th August 2021, with COVID-enforced pause 16th March 2020 to 9th July 2020
Secondary outcomes
Mortality and ΔSOFA
- Narrowly favoured the control arm, without clear statistical significance
Original publication
INHALE WP3, a multicentre, open-label, pragmatic randomised controlled trial assessing the impact of rapid, ICU-based, syndromic PCR, versus standard-of-care on antibiotic stewardship and clinical outcomes in hospital-acquired and ventilator-associated pneumonia. Intensive Care Med. Published 17 February 2025. doi:10.
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