Impact of a strategy using multiplex PCR on targeted antibiotic therapy for patients with suspected ventilator-associated pneumonia or hospital-acquired pneumonia requiring mechanical ventilation: a randomized, single-blind trial
Primary resultResult — go to the resultAbsolute difference 11.5 % 95% CI −0.03 to 26.2Authors' conclusion
Adding FAPP was not associated with a significant increase in targeted AMT at 24 h in patients with suspected VAP or vHAP, except in those with confirmed pneumonia.
Study context
- Population
- Immunocompetent adults with suspected ventilator-associated pneumonia (VAP) or vHAP146 analysed
- Participants
- 156 adults
- Comparison
- FilmArray Pneumonia Panel (FAPP) plus conventional microbiology vs conventional microbiology alone
- Interventionn = 74
- Controln = 72reference
- Primary endpoint
- Proportion of patients receiving targeted antimicrobial therapy (AMT)
- Follow-up
- 24 h after inclusion
Methodological detailsopen-label, multicentre, single-blind, 10 did not provide consent for continued participation
- Open-label
- Multicentre
- Single-blind
- 10 did not provide consent for continued participation
Primary result
As reported in the abstract
24 h
Absolute difference
11.5 %
95% CI −0.03 to 26.2
P = 0.13
By group
Intervention vs Control
absolute difference 11.5 % (95% CI −0.03 to 26.2); P = 0.13
Secondary outcomes
- Did not differ significantly
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Impact of a strategy using multiplex PCR on targeted antibiotic therapy for patients with suspected ventilator-associated pneumonia or hospital-acquired pneumonia requiring mechanical ventilation: a randomized, single-blind trial. Intensive Care Med. Published 20 August 2026. doi:10.
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