Assessing FilmArray Pneumonia+ panel dynamics during antibiotic treatment to predict clinical success in ICU patients with ventilated hospital-acquired pneumonia and ventilator-associated pneumonia: a multicenter prospective study
Authors' conclusion
FA-PP provides rapid and accurate diagnostics, but repeated testing did not predict clinical outcomes during treatment, however our small sample size limited the study power.
Study context
- Population
- ICU patients with ventilator-associated pneumonia (VAP) or ventilated hospital-acquired pneumonia (vHAP), April 2022 to June 2024
- Participants
- 93 patients
- Exposure
- FilmArray® Pneumonia + panel (FA-PP) vs Culture
- Outcome
- Correlation between quantitative changes in FA-PP results and clinical success
Methodological detailsmulticentre, 4 ICUs, Mixed ordinal logistic regression, endotracheal aspirates (ETAs) sampled on days 0, 1, 3, 7 and 10 and 3 days after stopping antibiotics
- Multicentre
- 4 ICUs
- Mixed ordinal logistic regression
- ETAs sampled on days 0, 1, 3, 7 and 10 and 3 days after stopping antibiotics
Main finding
As reported in the abstract
Correlation of quantitative changes with clinical success
- FA-PP and culture quantification declined over time
- p < 0.0001
- Clinical success
- 60.2% (n = 56)
Observational data: associations, not effects.
Further findings
| Outcome | FA-PP |
|---|---|
| Diagnostic performance of FA-PP vs culture at diagnosis · day 0 | |
| Sensitivity | 94% [95% CI: 87-97] |
| Specificity | 98% [95% CI: 97-98] |
- Diagnostic performance of FA-PP in follow-up ETAs · during antibiotic treatment
- 94% · sensitivity · specificity 95%
Quantitative concordance FA-PP vs culture
- Concordance at culture threshold 10⁴ DNA copies/ml
- 22.9%
- Concordance at ≥ 10⁷ DNA copies/ml
- 100%
ICU mortality
- ICU mortality rate
- 25.8% (n = 24)
Original publication
Assessing FilmArray Pneumonia+ panel dynamics during antibiotic treatment to predict clinical success in ICU patients with ventilated hospital-acquired pneumonia and ventilator-associated pneumonia: a multicenter prospective study. Crit Care. Published 12 July 2025. doi:10.
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