Sepsis & infection

Consideration of Sociodemographics in Machine Learning-Driven Sepsis Risk Prediction

Crit Care MedPublished Systematic review of studies extracted from review articles

Authors' conclusion

The inclusion of sociodemographic data and stratified assessment of performance-essential steps in developing equitable risk prediction tools-are possible but have yet to be consistently adopted.

Study context

Population
Studies of machine learning (ML)/artificial intelligence (AI) prediction of sepsis, sepsis-related outcomes or sepsis treatment in adults, extracted from reviews published January 1, 2023–June 30, 2024studies from 13 reviews
Participants
120 participants
Outcome
Reporting of sample sociodemographics, sociodemographics as predictors, stratification by sociodemographics or fairness metrics, and lack of sociodemographic consideration as a limitation
Methodological detailsmeta-research, two reviewers, predefined extraction forms, 13 of 96 review studies (14%) met inclusion criteria: 6 systematic and 7 narrative reviews; 120 of 170 extracted studies (71%) included
  • Meta-research
  • Two reviewers
  • Predefined extraction forms
  • 13 of 96 review studies (14%) met inclusion criteria: 6 systematic and 7 narrative reviews; 120 of 170 extracted studies (71%) included

Pooled result

As reported in the abstract

Reporting of sociodemographics
Reported a measure of geography or where data was collected
99 of 120 (83%)
Reported sex/gender
80 (67%)
Reported race/ethnicity
24 (20%)
Reported other sociodemographics
4 (3%)
Stratified performance results by sociodemographics
3 (2%)
Reported formal fairness metrics
0
Reported lack of geographic heterogeneity as a limitation
39/120, 33%

Original publication

Consideration of Sociodemographics in Machine Learning-Driven Sepsis Risk Prediction. Crit Care Med. Published 9 June 2025. doi:10.1097/ccm.0000000000006741

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