Hemodynamics, fluids & transfusion
Continuous versus bolus norepinephrine administration to treat hypotension after induction of general anaesthesia in low-to-moderate risk noncardiac surgery patients: a randomised trial
Authors' conclusion
Continuous administration of norepinephrine, compared with repeated manual bolus doses, did not reduce postinduction hypotension in low-to-moderate risk noncardiac surgery patients who had intermittent oscillometric blood pressure monitoring.
Study context
- Population
- Low-to-moderate risk patients undergoing elective noncardiac surgery under GA, intermittent oscillometric BP monitoring261 had complete data
- Participants
- 276 patients
- Comparison
- Continuous norepinephrine infusion vs manual bolus norepinephrine during induction of GA
- Primary endpoint
- Postinduction hypotension: area under a MAP of 65 mm Hg
- Follow-up
- Within 15 min after starting induction of GA
Methodological detailsblinded continuous noninvasive BP monitoring
- Blinded continuous noninvasive BP monitoring
Primary result
As reported in the abstract
Area under a MAP of 65 mm Hg · 15 min after induction
P = 0.070
Further findings
Duration of MAP <65 mm Hg · 15 min after starting induction of GA
- Median duration of MAP <65 mm Hg, continuous vs bolus: 1.0 (0.0-2.5) min vs 1.4 (0.2-3.2) min
- P = 0.052
Original publication
Continuous versus bolus norepinephrine administration to treat hypotension after induction of general anaesthesia in low-to-moderate risk noncardiac surgery patients: a randomised trial. Br J Anaesth. Published 2 May 2025. doi:10.
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