Corticosteroids for adult patients hospitalised with non-viral community-acquired pneumonia: a systematic review and meta-analysis
Pooled result · Short-term mortalityResult — go to the resultRelative risk 0.82 95% CI 0.74–0.91Authors' conclusion
Corticosteroids probably reduced short-term mortality and reduce the need for invasive mechanical ventilation in hospitalised patients with CAP.
Study context
- Population
- Hospitalised adults with suspected or probable non-viral community-acquired pneumonia (CAP)
- Participants
- 7,519 adults · 30 RCTs
- Comparison
- Corticosteroids vs no corticosteroids
- Outcome
- Short-term mortality
- Follow-up
- 28-30 days
Methodological detailsrandom effects pairwise meta-analysis, Bayesian meta-analysis, dose-response meta-analysis, GRADE
- Random effects pairwise meta-analysis
- Bayesian meta-analysis
- Dose-response meta-analysis
- GRADE
Pooled result
As reported in the abstract
Relative risk
0.82
95% CI 0.74–0.91
Corticosteroids vs Control
RR 0.82 (95% CI 0.74–0.91)
Further pooled results
| Outcome | RR (95% CI) | |
|---|---|---|
| Longer-term mortality · 60-90 dayLow certainty | 0.89 (0.76–1.03) | |
| Need for invasive mechanical ventilationHigh certainty | 0.63 (0.48–0.82) | |
| 0.512Relative risk (log scale) |
| Outcome | MD (days fewer) (95% CI) | |
|---|---|---|
| ICU LOSLow certainty | 1.53 (0.31–2.75) | |
| Hospital LOSLow certainty | 2.30 (0.81–3.81) | |
| −2024Difference, days fewer (linear scale) |
Safety
| Outcome | RR (95% CI) | |
|---|---|---|
| Hyperglycaemia requiring interventionModerate certainty | 1.32 (1.12–1.56) | |
| Secondary infectionsModerate certainty | 0.97 (0.85–1.11) | |
| 0.512Relative risk (log scale) |
Original publication
Corticosteroids for adult patients hospitalised with non-viral community-acquired pneumonia: a systematic review and meta-analysis. Intensive Care Med. Published 5 May 2025. doi:10.
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