Perioperative medicine & outcomes
Cost‐effectiveness analysis of total intravenous vs. inhalation anaesthesia among adults aged ≥ 50 y undergoing major non‐cardiac surgery
Authors' conclusion
Total intravenous and inhalational anaesthesia show comparable cost-effectiveness for adults aged ≥ 50 y undergoing major non-cardiac surgery.
Study context
- Population
- Adults aged ≥ 50 y undergoing major non-cardiac surgery, UK NHSrandomised
- Participants
- 2,507 adults
- Comparison
- TIVA vs inhalational anaesthesia
- TIVAn = 1,253
- Inhalational anaesthesian = 1,254reference
- Primary endpoint
- Incremental cost-effectiveness (incremental cost and QALYs; EQ-5D-5L, area under the curve)
- Follow-up
- 6 months
Methodological detailsNHS and personal social services perspective, 6-month time horizon, imputed datasets, bootstrapping
- NHS and personal social services perspective
- 6-month time horizon
- Imputed datasets
- Bootstrapping
Primary result
As reported in the abstract
Cost-effectiveness (NHS and personal social services perspective)
Incremental cost
-£145
95%CI -£1510-£1220
Incremental QALYs
−0.001
95%CI −0.008–0.005
TIVA probability of cost-effectiveness at standard willingness-to-pay thresholds
56-57%
Further findings
Sensitivity analyses (complete-case, societal perspective)
- Consistent findings of equivalence
Original publication
Cost‐effectiveness analysis of total intravenous vs. inhalation anaesthesia among adults aged ≥ 50 y undergoing major non‐cardiac surgery. Anaesthesia. Published 12 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →