COVID-19 associated pulmonary aspergillosis in critically-ill patients: a prospective multicenter study in the era of Delta and Omicron variants
An erratum to this article was published (Ann Intensive Care, 14 Jun 2024 ↗)
Authors' conclusion
We report a lower prevalence of CAPA (5.1%) among critically-ill COVID-19 patients than previously reported, mainly affecting intubated-patients. Duration of mechanical ventilation and ICU stay were significantly longer in CAPA patients.
Study context
- Population
- Critically ill COVID-19 patients in 36 French Intensive Care Units (ICUs), December 7th, 2021 to April 26th 2023 (Delta and Omicron era)
- Participants
- 566 patients · 36 ICUs
- Exposure
- CAPA vs non-CAPA
- Outcome
- Prevalence of CAPA
Methodological detailsmulticentre, observational
- Multicentre
- Observational
Main finding
As reported in the abstract
Prevalence of CAPA, all patients
5.1%
95% CI 3.4–7.3
Prevalence of CAPA among patients requiring invasive mechanical ventilation
9.1%
Observational data: associations, not effects.
Further findings
Characteristics of CAPA vs non-CAPA (univariable)
- CAPA patients more frequently immunosuppressed and more frequently required invasive mechanical ventilation, vasopressors and RRT during ICU stay
Factors independently associated with CAPA (multivariable logistic regression)
- SAPS II at ICU admission, immunosuppression and SARS-CoV-2 Delta variant independently associated with CAPA
Day-28 mortality
- CAPA not significantly associated with day-28 mortality
Duration of mechanical ventilation and ICU stay
- Longer duration of mechanical ventilation and ICU stay in CAPA patients
Original publication
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