Respiratory failure & ventilation
Critically ill adult patients with acute leukemia: a systematic review and meta-analysis
Authors' conclusion
Acute respiratory failure is the main reason for ICU admission in patients with acute leukemia. Mechanical ventilation is the first life-sustaining therapy to be used, and also a strong predictor of mortality.
Study context
- Population
- Adult critically ill patients with acute leukemia admitted to the intensive care unit (ICU)
- Participants
- 24,861 patients · 136 studies
- Outcome
- All-cause ICU mortality
Methodological detailsproportional meta-analysis, random effects model, meta-regression
- Proportional meta-analysis
- Random effects model
- Meta-regression
Pooled result
As reported in the abstract
ICU mortality
ICU mortality, metanalytical proportion (51 studies, 6,668 patients, 2,956 died)
52%
95% CI
47%; 57%
I2
93%
Further pooled results
Type of leukemia
- Acute myeloid leukemia, 16,269 patients
- 66%
- Acute lymphoblastic leukemia, 835 patients
- 3%
- Type not specified, 7,757 patients
- 31%
Reasons for ICU admission
- Acute respiratory failure
- 70%
- Acute circulatory failure
- 25%
Organ support
- Invasive mechanical ventilation
- 65%
- Vasopressors
- 53%
- RRT
- 23%
Meta-regression of ICU mortality
- Variables influencing ICU mortality: year of publication and intubation rate
Original publication
Critically ill adult patients with acute leukemia: a systematic review and meta-analysis. Ann Intensive Care. Published 16 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →