Cryoanalgesia Increases Neuropathic Pain in Adults Undergoing Minimally Invasive Surgery: A 1-Year Follow-up of a Randomized Study
Authors' conclusion
Cryoanalgesia increased neuropathic pain incidence and severity through 1 year.
Study context
- Population
- Adults undergoing minimally invasive thoracic surgery84 with 12-month data
- Participants
- 40 vs 44
- Comparison
- SOC intercostal nerve block plus cryoanalgesia vs SOC alone
- Cryoanalgesia (CRYO)n = 40
- SOCn = 44reference
- Primary endpoint
- Neuropathic pain (LANSS ≥12) and pain severity (VAS) at 1-year follow-up
- Follow-up
- 12 months
Methodological details1-year follow-up
- 1-year follow-up
Primary result
As reported in the abstract
LANSS ≥12 (neuropathic pain)
P = 0.002
Further findings
LANSS ≥12 · 3 months
P = 0.031
LANSS ≥12 · 6 months
0.010
Median
| Outcome | CRYO | SOC | P value |
|---|---|---|---|
| LANSS score · 12 months | 4.5 | 0 | P < 0.001 |
| LANSS score · 3 months | 10 | 0.5 | P = 0.003 |
| LANSS score · 6 months | 8 | 0 | P < 0.001 |
- Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) score: 36 SOC, 40 CRYO with data
- LANSS score: 42 SOC, 40 CRYO with data
Visual Analog Scale (VAS) pain score · 3, 6 and 12 months
- Higher VAS in CRYO at 3 months
- P = 0.012
- Higher VAS in CRYO at 6 months
- 0.028
- No higher VAS at 12 months
- P = 0.168
Original publication
Cryoanalgesia Increases Neuropathic Pain in Adults Undergoing Minimally Invasive Surgery: A 1-Year Follow-up of a Randomized Study. Ann Surg. Published 7 November 2025. doi:10.
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