ICU sedation, delirium & recovery
A cumulative-morbidity plasma proteomic architecture of critical-illness susceptibility: a UK biobank proteome-wide study of critical-care exposure, in-hospital death, and sex-specific signals
Main finding · Ever critical-care exposureResult — go to the resultOdds ratio 1.37 95% CI 1.33–1.42Authors' conclusion
Baseline plasma proteins measured a median of more than 10 years before any critical-care episode were associated with later critical-care exposure and in-hospital death during a critical-care hospitalisation, with a biologically coherent pattern spanning stress-response, renal, epithelial, inflammatory, and tissue-remodelling pathways and a secondary female-predominant interaction signal among the leading proteins.
Study context
- Population
- UK Biobank participants linked to Hospital Episode Statistics critical-care records2,986 with ≥1 critical-care episode
- Participants
- 53,000 participants
- Exposure
- Baseline plasma protein levels and later critical-care outcomes
- Outcome
- Ever critical-care exposure
Methodological detailsprospective cohort, UK Biobank, logistic regression primary analyses, Bonferroni correction, sensitivity analyses: Cox models, cross-validated LASSO, sex-interaction testing, reverse-causation proxy analyses
- Prospective cohort
- UK Biobank
- Logistic regression primary analyses
- Bonferroni correction
- Sensitivity analyses: Cox models, cross-validated LASSO, sex-interaction testing, reverse-causation proxy analyses
Main finding
As reported in the abstract
Odds ratio
1.37
95% CI 1.33–1.42
P = 2.82 × 10⁻68
Per SD, as printed
- Proteins surviving Bonferroni correction
- 545
Observational data: associations, not effects.
Further findings
In-hospital death during a critical-care hospitalisation
- Bonferroni-significant proteins, again led by GDF15
- 18
Prolonged critical care
- Markedly attenuated signal
Sex interaction
- Sex-interaction effects predominantly stronger in women
Reverse-causation analysis (exploratory)
- Null estimates, indicating unresolved residual confounding
- Exploratory
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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