Pediatric anesthesia & critical care
Daily Sedation Interruption vs Continuous Sedation in Pediatric Patients Receiving Mechanical Ventilation: A Systematic Review and Meta-analysis
Pooled result · Length of PICU stay and duration of MV (primary outcomes)Result — go to the resultMD −1.45 days 95% CI −2.75 to −0.15Authors' conclusion
This systematic review and meta-analysis found that use of DSI in pediatric patients was associated with reduced length of PICU stay with no increase in adverse events.
Study context
- Population
- Patients aged 18 years or younger receiving invasive mechanical ventilation (MV) in the pediatric intensive care unit (PICU)
- Participants
- 2,810 patients · 6 randomized clinical trials (RCTs)
- Comparison
- Daily sedation interruption (DSI) vs continuous intravenous (IV) sedation
- Outcome
- Duration of MV and length of PICU stay
Methodological detailsrandom-effects model, PRISMA
- Random-effects model
- PRISMA
Pooled result
As reported in the abstract
Length of PICU stay and duration of MV (primary outcomes)
MD
−1.45 days
95% CI −2.75 to −0.15
P = 0.03
DSI vs Continuous IV sedation
MD −1.45 days (95% CI −2.75 to −0.15); P = 0.03
Further pooled results
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| Mortality | 0.89 (0.55–1.46) | P = 0.65 | |
| 0.512Relative risk (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Daily Sedation Interruption vs Continuous Sedation in Pediatric Patients Receiving Mechanical Ventilation: A Systematic Review and Meta-analysis. JAMA Netw Open. Published 1 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →