Definitions of massive transfusion in adults with critical bleeding: a systematic review
Authors' conclusion
Transfusion of ≥ 10 RBC units within 24 h was the most commonly used definition in published RCTs, while lower RBC volumes are being used in ongoing RCTs.
Study context
- Population
- Adults with major bleeding who received, or were anticipated to receive, massive transfusion (MT) in any clinical setting30 trials (19 published, 11 ongoing)
- Outcome
- Definitions of MT used in randomised controlled trials (RCTs)
Methodological detailsDatabases searched from inception until 11 August 2022
- Databases searched from inception until 11 August 2022
Pooled result
As reported in the abstract
Definitions of MT
Different definitions of MT identified across published and ongoing trials
15
Published trials using ≥ 10 RBC units in 24 h (most common; all in trauma)
9 of 19
Ongoing trials using 3-5 RBC units (most common)
7
Ongoing trials with timing for transfusion poorly defined or not provided
5
Further pooled results
Clinical setting
- Trauma most common in published trials; obstetrics in ongoing trials
Original publication
Definitions of massive transfusion in adults with critical bleeding: a systematic review. Crit Care. Published 5 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →