Hemodynamics, fluids & transfusion
Rapid Update and Revision of: Thromboelastography or Rotational Thromboelastometry Guided Algorithms in Bleeding Patients—An Updated Systematic Review With Meta‐Analysis and Trial Sequential Analysis
Pooled resultResult — go to the resultRelative risk 0.76 95% CI 0.63–0.92Authors' conclusion
TEG-/ROTEM-guided transfusion algorithms may reduce the risk of mortality, bleeding volume, and the need for fresh frozen plasma, platelets, and surgical reintervention, but the evidence is very uncertain.
Study context
- Population
- Bleeding pediatric and adult patients, primarily elective cardiac surgery
- Participants
- 3,096 participants · 35 RCTs
- Comparison
- TEG/ROTEM-guided transfusion vs standard of care
- Outcome
- Mortality
Methodological detailstrial sequential analysis, Cochrane methodology, PRISMA, GRADE
- Trial sequential analysis
- Cochrane methodology, PRISMA, GRADE
Pooled result
As reported in the abstract
Relative risk
0.76
95% CI 0.63–0.92
TEG/ROTEM vs Standard of care
RR 0.76 (95% CI 0.63–0.92)
Further pooled results
| Outcome | RR (95% CI) | |
|---|---|---|
| Transfused FFPI2: 94% | 0.52 (0.35–0.76) | |
| Transfused plateletsI2: 60% | 0.69 (0.55–0.87) | |
| Surgical reinterventionI2: 0% | 0.63 (0.45–0.88) | |
| 0.20.5125Relative risk (log scale) |
| Outcome | Standard mean difference (95% CI) | |
|---|---|---|
| BleedingI2: 72% | −0.31 (−0.51 to −0.11) | |
| −1−0.500.5Difference (linear scale) |
Original publication
Rapid Update and Revision of: Thromboelastography or Rotational Thromboelastometry Guided Algorithms in Bleeding Patients—An Updated Systematic Review With Meta‐Analysis and Trial Sequential Analysis. Acta Anaesthesiol Scand. Published 26 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →